interleukin 13 การใช้

• CCL6 can also be induced in the mouse lung by the cytokine interleukin 13.
• For instance, a pair of redundant cytokines are interleukin 4 and interleukin 13.
• Interleukin 13 ( IL-13 ) is a pleiotropic cytokine that may be important in the regulation of the inflammatory and immune responses.
• "' Tralokinumab "'is a human monoclonal antibody which targets the cytokine interleukin 13, and is designed for the treatment of asthma and other inflammatory diseases.
• TAMs have been induced in vitro by exposing macrophage progenitors to different immune regulatory cytokines, such as interleukin 4 ( IL-4 ) and interleukin 13 ( IL-13 ).
• This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells.
• BLT2 receptor knockout mice exhibit attenuated ovalbumen-induced allergic airway eosinophilia and Interleukin 13 ( IL-13 ) content in their bronchoalveolar lavage fluid compared with wild type mice and CD4-positive T cells isolated from the knockout mice showed a reduction IL-13 production but there was no change in the bronchospasm response to ovalbumin in these mice.
• It dilates airways ( bronchodilation ) contracted by the allergic mediator, histamine; inhibits Immunoglobulin E-activated mast cells from releasing histamine and leukotrienes ( viz ., LTC4, LTD4, and LTE4 ), all of which have bronchoconstricting and otherwise pro-allergic actions; inhibits pro-allergic eosinophil apoptosis, chemotaxis, and release of pro-allergic granule contents; and reduces release of the pro-allergic cytokines Interleukin 5, Interleukin 4, and interleukin 13 from human blood mononuclear cells.